Chronological by weight of evidence. Every card links to the original journal — read them yourself;
that's the point.
B
A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel
Hunt, Flint, Logan & King · Frontiers in Veterinary Science · 2023
n = 40 Placebo-controlled, blinded crossover 4 mg/kg, single dose
A single 4 mg/kg dose before separation and car-travel tests reduced several stress indicators (including serum cortisol and stress-related behaviors) versus placebo. Effects were modest and measure-dependent — not a sedative-style knockout.
C
The impact of feeding cannabidiol (CBD) containing treats on canine response to a noise-induced fear response test
Morris et al. · Frontiers in Veterinary Science · 2020
n = 32 Placebo-controlled, randomized ~1.4 mg/kg (treats)
CBD treats alone did NOT significantly reduce measured fear responses to noise versus placebo. An honest negative: the fireworks use-case has the weakest supporting evidence, and dose/format may matter.
B-
Cannabis sativa L. may reduce aggressive behaviour towards humans in shelter dogs
Corsetti et al. · Scientific Reports · 2021
n = 24 Controlled, shelter population Titrated CBD oil, daily
Shelter dogs receiving CBD showed reduced aggressive behavior toward humans versus control. Stress behaviors overall didn't change significantly — a real but narrow effect in a high-stress population.
B
Pharmacokinetics, safety, and clinical efficacy of cannabidiol treatment in osteoarthritic dogs
Gamble et al. (Cornell) · Frontiers in Veterinary Science · 2018
n = 22 Randomized, placebo-controlled, double-blind crossover 2 mg/kg twice daily
The landmark Cornell trial: 2 mg/kg twice daily significantly reduced pain scores and increased activity in osteoarthritic dogs, with no observed serious adverse effects. Pain, not anxiety — but it anchors dosing and safety.
A-
Preliminary investigation of the safety of escalating cannabinoid doses in healthy dogs
Vaughn, Kulpa & Paulionis · Frontiers in Veterinary Science · 2020
n = 20 Placebo-controlled dose escalation Up to ~62 mg/kg (escalating)
CBD-dominant oil was well tolerated even at doses far above anything used for anxiety; the most common findings were mild GI upset and elevated ALP liver values at high doses — the reason vets monitor liver enzymes.
A-
Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
Bradley et al. · Frontiers in Veterinary Science · 2022
n = 40 Randomized, placebo-controlled, 6 months 4 mg/kg daily, 26 weeks
Six months of daily 4 mg/kg CBD was well tolerated; ALP elevations occurred in some dogs without clinical signs. The best long-term safety data we have.
B-
Single-dose pharmacokinetics and preliminary safety assessment with use of CBD-rich hemp nutraceutical in healthy dogs and cats
Deabold et al. · Animals · 2019
n = 8 Pharmacokinetic study 2 mg/kg twice daily
Established absorption and 12-week safety basics in dogs AND cats — the study most cat guidance leans on. Cats absorbed less and cleared faster than dogs.
I
Owner-reported outcomes with hemp-derived CBD in dogs
Kogan et al. · AHVMA Journal (owner surveys) · 2020
n = 1200 Survey (no placebo control) Varied
Large owner surveys consistently report perceived calming benefit — but owner perception is exactly what placebo effects inflate. We treat surveys as demand signal, not evidence.